Tetrahydrofuran → 1-Boc-4-[Hydroxy-(4-trifluoromethoxyphenyl)methyl]piperidine
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:8][C:9]([F:10])([F:11])[F:12])[cH:6][cH:7]1.[C:18]([CH3:19])([CH3:20])([CH3:21])[O:22][C:23](=[O:24])[N:25]1[CH2:26][CH2:27][CH:28]([CH:31]=[O:32])[CH2:29][CH2:30]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:13][CH2:14][CH2:15][CH2:16][Li:17]>>[c:2]1([CH:31]([CH:28]2[CH2:27][CH2:26][N:25]([C:23]([O:22][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:24])[CH2:30][CH2:29]2)[OH:32])[cH:3][cH:4][c:5]([O:8][C:9]([F:10])([F:11])[F:12])[cH:6][cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-817989c7f23f4215a833d614813a55af
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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