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Hydrochloric Acid → HCID 70637301, compound

HRID 1580238
Notes
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Reaction equation

HRID 1580238 reaction equation
[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1.[OH-].[K+].[ClH:29].[Cl-].[Na+]>CO.O>[ClH:29].[NH2:1][CH:2]([CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:3][CH2:4][C@@H:5]1[C@@H:9]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:8](=[O:21])[CH2:7][CH2:6]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14797Potassium HydroxideHCID 18594875HCID 18594875, compound

Product 1

HCID 70637301HCID 70637301, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)
Solvent

Procedure

A solution of 1 g. of ethyl 15-amino-9-oxo-prostanoate (Example 143) in 15 ml. of methanol-water (1:1) containing 445 mg. of potassium hydroxide is stirred at ambient temperature for 18 hours. The solution is acidifed with hydrochloric acid, saturated with sodium chloride, and extracted several times with methylene chloride. The organic phase is dried with anhydrous magnesium sulfate and taken to dryness to give a viscous oil; λ max. 2.80 - 3.70 (broad), 5.75, and 5.87 μ.

Workup

  1. extractionextracted several times with methylene chloride
  2. dry with materialThe organic phase is dried with anhydrous magnesium sulfate
  3. customto give a viscous oil

Sources & evidence

ORD record
ord-e7f969c7bf5f4de29d0239e1cfc7bc11
Source dataset
uspto-grants-1976_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US03932472

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes