Dimethylformamide → 6-Isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline-8-carbaldehyde
Reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:17]([CH3:19])[CH3:18])[CH:5]=[C:6]2[C:11]=1[N:10]([CH2:12][CH2:13][CH3:14])[CH2:9][CH2:8][C:7]2([CH3:16])[CH3:15].CN(C)[CH:22]=[O:23]>>[CH:17]([C:4]1[CH:5]=[C:6]2[C:11](=[C:2]([CH:22]=[O:23])[CH:3]=1)[N:10]([CH2:12][CH2:13][CH3:14])[CH2:9][CH2:8][C:7]2([CH3:16])[CH3:15])([CH3:19])[CH3:18]Participants
3
Procedure
Following General Procedure B, 8-bromo-6-isopropyl-4,4-dimethyl-1-n-propyl-1,2,3,4-tetrahydro-quinoline (Intermediate 6, 5.64 g, 19.6 mmol) and N,N-dimethylformamide (6.0 g, 78.5 mmol) were reacted to produce the title compound as a yellow oil.
Workup
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