Ethyl bromoacetate → Acetic acid, 2-(4-cyanophenoxy)-, ethyl ester
Reaction equation
[CH2:1]([O:3][C:4](=[O:37])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2N(C(=O)C(C)C)C(C3C=CC(Cl)=CC=3)C(C3C=CC(Cl)=CC=3)[N:17]=2)=[CH:9][CH:8]=1)[CH3:2].OC1C=CC(C#N)=CC=1.BrCC(OCC)=O>>[C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:37])=[CH:8][CH:9]=1)#[N:17]Participants
4
Procedure
{4-[4,5-Bis-(4-chloro-phenyl)-1-isobutyryl-4,5-dihydro-1H-imidazol-2-yl]-phenoxy}-acetic acid ethyl ester. HR-MS (ES, m/z) calculated for C29H29N2O4Cl2[(M+H)+]539.1499, observed 539.1506. The starting ethyl (4-cyano-phenoxy)-acetate was prepared from 4-hydroxy-benzonitrile and ethyl bromoacetate as described in Kirkiacharian, S.; Goma, J. R. et al. Ann. Pharm. Fr. 1989, 47, 16-23.