Hydrazine hydrate (1:1) → 3-(Pyridin-3-yl)propan-1-amine
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][N:10]2C(=O)C3C(=CC=CC=3)C2=O)[CH:2]=1.O.NN>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][NH2:10])[CH:2]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 11.3 g of 2-[3-(3-pyridyl)propyl]-1H-isoindole-1,3(2H)-dione and 10.1 g of hydrazine hydrate was refluxed in 200 ml of ethanol for 6 hours, allowed to cool, and was filtered. The filtrate was concentrated and the residue distilled to give 4.77 g (70%) of 3-pyridinepropanamine, bp 84°-86° C./0.35 mm.
Workup
- temperatureto cool
- filtrationwas filtered
- concentrationThe filtrate was concentrated
- distillationthe residue distilled
Sources & evidence
- ORD record
- ord-fcbc6f61b72c42cc80c77c5ac8c63246
- Source dataset
- uspto-grants-1985_11
- Patent number
- US04551460
Reaction notes
Loading…