beta-D-Galp-(1->3)-D-GlcpN → D-Galactosamine

HRID 1585189Notes

Reaction equation

[O:1]([C@H:13]1[C@H:19]([OH:20])[C@@H:18]([CH2:21][OH:22])[O:17][CH:15]([OH:16])[C@@H:14]1[NH2:23])[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O.[O:24]([C@H:36]1[C@@H:42]([OH:43])[C@@H:41]([CH2:44][OH:45])[O:40][CH:38]([OH:39])[C@@H:37]1[NH2:46])[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O>>[OH:16][CH:15]1[O:17][C@H:18]([CH2:21][OH:22])[C@@H:19]([OH:20])[C@H:13]([OH:1])[C@H:14]1[NH2:23].[OH:39][CH:38]1[O:40][C@H:41]([CH2:44][OH:45])[C@H:42]([OH:43])[C@H:36]([OH:24])[C@H:37]1[NH2:46]

Participants

Reactant 2

HCID 91861991beta-D-Galp-(1->3)-D-GlcpN

HCID 91862027GlyTouCan:G14446DQ

Product 2

HCID 24154D-Galactosamine

HCID 439213D-Glucosamine

Procedure

Synthesis of Galβ1-3GlcNH2 βSEt and Galβ1-3GalNH2 βSEt. See example 1, similar conditions and enzyme may be used, but instead GlcNH2 βSEt, or GalNH2 βSEt to obtain the latter product, is used as the acceptor. Here, extraction is less favorable for isolation, and instead ion-exchanger as above may be used followed by e.g. precipitation or a second chromatographic step.

Sources & evidence

ORD record: ord-a5ab09a504e049068eafe2b223197765
Source dataset: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05936075

Reaction notes

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