Acetamide → N-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamide

HRID 15867

Reaction equation

HRID 15867 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]([F:27])=[C:6]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:25]=[CH:24][CH:23]=[C:22]4[C:17]=3[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]4)[CH2:12][CH2:11]2)[CH:7]=1.[C:28]([NH2:31])(=[O:30])[CH3:29]>>[F:27][C:5]1[CH:4]=[CH:3][C:2]([NH:31][C:28](=[O:30])[CH3:29])=[CH:7][C:6]=1[CH2:8][CH2:9][N:10]1[CH2:15][CH2:14][N:13]([C:16]2[CH:25]=[CH:24][CH:23]=[C:22]3[C:17]=2[CH:18]=[CH:19][C:20]([CH3:26])=[N:21]3)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 178AcetamideHCID 574443505-{4-[2-(5-Bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline

Product 1

HCID 57444349N-(4-Fluoro-3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)acetamideYield 66%

Procedure

The title compound was prepared in 66% yield according to the general procedure for the preparation of the amides, ureas and carbamates (Method A) starting from 5-{4-[2-(5-bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline and acetamide.

Sources & evidence

ORD record
ord-800a26bd045545dd92f90a7e97ea1aed
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Linked notes

Loading…