p-Toluenesulfonic acid → 1-Methyl-5-[2-(4-trifluoromethyl-phenyl)-ethylamino]-5,6,7,8-tetrahydro-1H-quinolin-2-one

A mixture of 2-(4-trifluoromethylphenyl)ethylamine (4.1 g), 5,6,7,8-tetrahydro-1-methyl-5-oxo-2(1H)-quinolinone (3.0 g), and para-toluenesulfonic acid (256 mg) was heated in refluxing toluene (50 ml), was azeotroptic removal or water, for 40 hrs. An additional 2.0 g of the amine was added and the mixture was refluxed for 36 hr. The solution was cooled, and the mixture was concentrated in vacuo. Sodium borohydride (0.6 g) was added to a solution of the residue in ethyl alcohol (50 ml), and the resulting mixture was stirred at room temperature for 1 hr. The mixture was concentrated in vacuo, the residue was quenched with water, and the mixture was extracted with dichloromethane. The combined organic layers were washed with brine, dried over anhydrous magnesium sulfate, filtered, and the filtrate was concentrated. The residue was recrystallized from ethyl acetate/hexanes to provide, in two crops, 3.8 g (65%) of product, mp 104°-106° C.

1. temperaturewas heated
2. customremoval or water
3. additionAn additional 2.0 g of the amine was added
4. temperaturethe mixture was refluxed for 36 hr
5. temperatureThe solution was cooled
6. concentrationthe mixture was concentrated in vacuo
7. additionSodium borohydride (0.6 g) was added to a solution of the residue in ethyl alcohol (50 ml)
8. concentrationThe mixture was concentrated in vacuo
9. customthe residue was quenched with water
10. extractionthe mixture was extracted with dichloromethane
11. washThe combined organic layers were washed with brine
12. dry with materialdried over anhydrous magnesium sulfate
13. filtrationfiltered
14. concentrationthe filtrate was concentrated
15. customThe residue was recrystallized from ethyl acetate/hexanes

ORD record

ord-5fcf858cf1824a46a075db5c2b8ac6c1

Source dataset

uspto-grants-1993_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05216164