Hydrochloric Acid → HCID 67721738, compound
Reaction equation
C([N:4]1[CH2:13][C@@H:12]([C:14]2[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([OH:21])[CH:15]=2)[C:11]2[C:6](=[C:7]([OH:23])[C:8]([OH:22])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])C.[ClH:24]>C(O)C>[OH2:3].[ClH:24].[OH:22][C:8]1[C:7]([OH:23])=[C:6]2[C:11]([C@@H:12]([C:14]3[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([OH:21])[CH:15]=3)[CH2:13][NH:4][CH2:5]2)=[CH:10][CH:9]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
(i) to 1.15 g of (R)-(-)-N-acetyl-7,8-dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline 1/4 hydrate were added 9 ml of 3N hydrochloric acid and 9 ml of ethanol, and the mixture was heated under an argon gas stream for 24 hours. After the reaction solution was cooled, the crystals which separated out were collected by filtration, affording 1.09 g of (R)-(+)-7,8-dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride monohydrate. [α]D20 =+15° (C=1, CH3OH)