6-Bromo-1-(1-imidazolyl)-3,4-dihydronaphthalene → 5-(1H-imidazol-1-yl)-7,8-dihydronaphthalene-2-carbonitrile
Reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1)=[CH:7][CH2:6][CH2:5]2.[C:17]([Cu])#[N:18]>CN1CCCC1=O>[C:17]([C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1)=[CH:7][CH2:6][CH2:5]2)#[N:18]Participants
4
Procedure
6-bromo-1-(1-imidazolyl)-3,4-dihydronaphthalene (Example 6) is converted by reaction with CuCN in 1-methylpyrrolidone into the title compound, m.p. 152°-153°.
Sources & evidence
- ORD record
- ord-41bd64185ace4e7ba68e6b058b140210
- Source dataset
- uspto-grants-1993_04
- Patent number
- US05206256
Reaction notes
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