Potassium Carbonate → HCID 17864576, compound
Reaction equation
[CH3:1][C:2]([N:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)([CH3:5])[C:3]#[CH:4].C(=O)([O-])[O-].[K+].[K+].Br[CH2:19][C:20]#[N:21]>C(C(C)=O)C>[CH3:5][C:2]([N:6]1[CH2:7][CH2:8][N:9]([CH2:19][C:20]#[N:21])[CH2:10][CH2:11]1)([CH3:1])[C:3]#[CH:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a suspension (10 mL) of 1-(1,1-dimethyl-2-propynyl)piperazine (350 mg, 2.3 mmol) and potassium carbonate (480 mg, 3.45 mmol) in methyl ethyl ketone (MEK) was added bromoacetonitrile (0.176 mL, 2.53 mmol), and the mixture was stirred at room temperature for 30 min. The reaction mixture was diluted with MEK and filtered. The filtrate was concentrated to give the title compound (0.439 g, quantitative) as a white solid.
Workup
- filtrationfiltered
- concentrationThe filtrate was concentrated
Sources & evidence
- ORD record
- ord-15682edb23f54c938c3e2e618456592d
- Source dataset
- uspto-grants-2007_11
- Patent number
- US07294629B2
Reaction notes
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