Piperidine → 4-(Piperidine-1-sulfonyl)benzonitrile
Reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9](Cl)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2].[NH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>C(Cl)Cl>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1)#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 4-cyanobenzenesulfonyl chloride (0.51 g, 2.5 mmol) and piperidine (0.60 mL, 517 mg, 6.04 mmol) in 10 mL methylene chloride was stirred overnight at ambient temperature. The organic layer was washed successively with water, 5% HCl and brine, dried (Na2SO4) and concentrated. The resulting white solid (0.61 g, 96%) was used with no further purification.
Workup
- washThe organic layer was washed successively with water, 5% HCl and brine
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- customThe resulting white solid (0.61 g, 96%) was used with no further purification
Sources & evidence
- ORD record
- ord-3ea63601232a458b8b96d1ba92c2708f
- Source dataset
- uspto-grants-2001_09
- Patent number
- US06288228B1
Reaction notes
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