Phosphoric Acid → Ascorbic acid 2-phosphate

Reaction equation

[O:1]=[C:2]1[O:8][C@H:7]([C@H:9]([CH2:11][OH:12])[OH:10])[C:5]([OH:6])=[C:3]1[OH:4].[P:13](=O)([OH:16])([OH:15])[OH:14]>>[CH2:11]([OH:12])[C@H:9]([OH:10])[C@H:7]1[O:8][C:2](=[O:1])[C:3]([O:4][P:13]([OH:16])([OH:15])=[O:14])=[C:5]1[OH:6]

Participants

Reactant 2

HCID 1004Phosphoric Acid

HCID 54670067L-Ascorbic Acid

Product 1

HCID 54679073Ascorbic acid 2-phosphate

Procedure

The solution E contained sodium salts of L-ascorbic acid, phosphoric acid and some L-ascorbyl 2-monophosphate, and can be recycled to the phosphorylation process for producing further ascorbyl monophosphate. The solution F contained only a small amount of the remaining L-ascorbic acid and can be recycled to the next batch for separation.

Sources & evidence

ORD record: ord-7e369f2e74954f9d9dc6a7a5d76b03a7
Source dataset: uspto-grants-2001_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06288243B1

Reaction notes

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