Trifluoroacetic acid → 4-(Carboxymethyloxy)-4'-cyano-biphenyl

HRID 1598395Notes

Reaction equation

HRID 1598395 reaction equation
C([O:5][C:6]([CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:12][CH:11]=1)=[O:7])(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[C:6]([CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=2)=[CH:14][CH:15]=1)([OH:7])=[O:5]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 640094Tert-butyl [(4'-cyanobiphenyl-4-yl)oxy]acetate

Product 1

HCID 432431004-(Carboxymethyloxy)-4'-cyano-biphenyl

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

32.9 g of 4-(tert.butyloxycarbonylmethyloxy)-4'-cyano-biphenyl dissolved in 250 ml of methylene chloride is mixed slowly with 137 ml of trifluoroacetic acid. After stirring for 3 hours, the reaction mixture is evaporated to dryness and the solid residue is triturated with water.

Workup

  1. customthe reaction mixture is evaporated to dryness
  2. customthe solid residue is triturated with water

Sources & evidence

ORD record
ord-1eb3d61987aa4b5a89fe81711f8f2f14
Source dataset
uspto-grants-1998_04
Patent number
US05736559

Reaction notes

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