Thionyl Chloride → 2,6-Dichloro-4-trifluoromethylbenzoyl chloride
Reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:18])=O>CN(C)C=O>[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([Cl:18])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 20.4 g of 2,6-dichloro-4-trifluoromethylbenzoic acid (11), 18.8 g of thionyl chloride and a small amount of anhydrous N,N-dimethylformamide was stirred at 90° C. overnight. The thionyl chloride was distilled off, and the resulting residue was distilled under reduced pressure to obtain 21.7 g of the desired compound in the form of a colorless liquid (quantitative yield).
Workup
- distillationThe thionyl chloride was distilled off
- distillationthe resulting residue was distilled under reduced pressure
Sources & evidence
- ORD record
- ord-7a32fdb285fa48ccaa7cbeffaa86ce13
- Source dataset
- uspto-grants-1998_04
- Patent number
- US05739083
Reaction notes
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