Hydrogen Bromide → 1-Azabicyclo[2.2.2]octan-3-one--hydrogen bromide (1/1)
Reaction equation
[BrH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C:4](=[O:10])[CH2:3]2>O>[BrH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C:4](=[O:10])[CH2:3]2Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
21.8 g (167 mol) of 62 percent hydrobromic acid was added dropwise to a solution of 19.0 g (152 mol) of 3-quinuclidinone in 50 ml of water and thereaction mixture was evaporated to dryness. The residue was suspended in 100 ml of tetrahydrofuran, filtered off on a frit and washed with 50 ml oftetrahydrofuran. After drying, 30.5 g (98 percent) of 3-quinuclidinone hydrobromide were isolated in the form of white crystals.
Workup
- custommixture was evaporated to dryness
- filtrationfiltered off on a frit
- washwashed with 50 ml oftetrahydrofuran
- customAfter drying
Sources & evidence
- ORD record
- ord-0e39107a044542928b8248e98d0bf763
- Source dataset
- uspto-grants-1998_04
- Patent number
- US05744606
Reaction notes
Loading…