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Potassium Carbonate → HCID 67595183, compound

HRID 1602361
Notes
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Reaction equation

HRID 1602361 reaction equation
Br[CH2:2][C:3]1[O:4][C:5](=[O:10])[O:6][C:7]=1[CH2:8][Br:9].[CH3:11][O:12][CH2:13][CH2:14][O:15][CH2:16][C:17]([OH:19])=[O:18].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:9][CH2:8][C:7]1[O:6][C:5](=[O:10])[O:4][C:3]=1[CH2:2][O:19][C:17](=[O:18])[CH2:16][O:15][CH2:14][CH2:13][O:12][CH3:11]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27642(2-Methoxyethoxy)acetic acidHCID 123258494,5-Bis(bromomethyl)-1,3-dioxol-2-one

Product 1

HCID 67595183HCID 67595183, compoundYield 28%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
25 °C

Procedure

4,5-Dibromomethyl-2-oxo-1,3-dioxolene (136 mg, 0.50 mmol) was dissolved in acetonitrile (5.0 mL). Thereto were added 2-methoxyethoxyacetic acid (0.057 mL, 0.50 mmol) and potassium carbonate (69 mg, 0.50 mmol) This mixture was stirred at 25° C. for 30 minutes. After the ordinary post-treatment, the reaction product was purified by thin-layer chromatography (developed with chloroform) to obtain Compound S-32 (45 mg, yield 28%).

Workup

  1. customAfter the ordinary post-treatment, the reaction product was purified by thin-layer chromatography (developed with chloroform)
  2. customto obtain Compound

Sources & evidence

ORD record
ord-703391f106844e818db34fc7e5c98253
Source dataset
uspto-grants-1999_11
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US05981558

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes