Hydroxyamine hydrochloride → HCID 136227082, compound

Reaction equation

[CH2:1]([C:3]1[CH:17]=[CH:16][C:6]([C:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=O)=[C:5]([OH:18])[CH:4]=1)[CH3:2].Cl.[NH2:20][OH:21]>>[CH2:1]([C:3]1[CH:17]=[CH:16][C:6]([C:7](=[N:20][OH:21])[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[C:5]([OH:18])[CH:4]=1)[CH3:2]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 12562657(4-Ethyl-2-hydroxyphenyl)(4-fluorophenyl)methanone

Product 1

HCID 136227082HCID 136227082, compound

Procedure

4-Ethyl-4'-fluoro-2-hydroxybenzophenone (21.0g, 80% pure) was treated with hydroxylamine hydrochloride (24.0g) similarly to Example 12, to give, after recrystallisation from benzene, the title compound as a white crystalline solid (10.7g), m.p. 130°-2°C.

Workup

customto give
customafter recrystallisation from benzene

Sources & evidence

ORD record: ord-3e74400b71e84ba2a3b77e5a62bc0b9f
Source dataset: uspto-grants-1976_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03951999

Reaction notes

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