Salicylic Acid → 2-(Dichloromethyl)phenol
Reaction equation
[C:1](O)(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4].S(Cl)(Cl)=O.[Cl-:15].[Al+3].[Cl-:17].[Cl-]>>[CH:1]([Cl:17])([Cl:15])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[OH:4]Participants
4
Procedure
A mixture of 10 grams of salicylic acid, 7 ml of thionyl chloride and 0.02 grams of aluminum chloride were heated at 40°-45° C. for 1.5 hours. The excess thionyl chloride was removed in vacuum and salicylyl chloride was obtained.
Workup
- temperaturewere heated at 40°-45° C. for 1.5 hours
- customThe excess thionyl chloride was removed in vacuum
Sources & evidence
- ORD record
- ord-a460c15847e04d4c8b20d56af5a52bf9
- Source dataset
- uspto-grants-1976_04
- Patent number
- US03953596
Reaction notes
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