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Water → 4-Methylthio-3-(trifluoromethyl)phenylboronic acid pinacol ester

HRID 16069
Notes
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Reaction equation

HRID 16069 reaction equation
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([B:9]([OH:11])[OH:10])=[CH:5][C:4]=1[C:12]([F:15])([F:14])[F:13].O[C:17]([C:20](O)([CH3:22])[CH3:21])([CH3:19])[CH3:18].C(OCC)C.O>O1CCOCC1>[CH3:18][C:17]1([CH3:19])[C:20]([CH3:22])([CH3:21])[O:11][B:9]([C:6]2[CH:7]=[CH:8][C:3]([S:2][CH3:1])=[C:4]([C:12]([F:15])([F:13])[F:14])[CH:5]=2)[O:10]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 962WaterHCID 3283Diethyl EtherHCID 6425PinacolHCID 748911694-Methylthio-3-(trifluoromethyl)phenylboronic acid

Product 1

HCID 672773014-Methylthio-3-(trifluoromethyl)phenylboronic acid pinacol ester

Reagents, catalysts & solvents 1

HCID 312751,4-Dioxane
On this pageParticipantsProcedureWorkupSources & evidenceReaction notes
Solvent

Procedure

The product of step b) (0.25 g) was heated in dioxan (2 ml) with pinacol (2 equiv) for 3 h. The solution was treated with diethyl ether and water. The organic layer was separated, washed with brine, dried (Na2SO4) and concentrated in vacuo. Yield 85 mg.

Workup

  1. customThe organic layer was separated
  2. washwashed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4377e4d71b804528910e589e09a43d88
Source dataset
uspto-grants-2010_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07737135B2

Reaction notes

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