L-Pyroglutamic Acid → N-[Hydroxy(5-hydroxy-3,4-dihydro-2H-pyrrol-2-yl)methylidene]glycine
Reaction equation
[NH:1]([C:6]([O:8]C(C)(C)C)=O)[CH2:2][C:3]([OH:5])=[O:4].[NH:13]1[C:17](=[O:18])[CH2:16][CH2:15][C@H:14]1C(O)=O>>[NH:13]1[C:17](=[O:18])[CH2:16][CH2:15][C@H:14]1[C:6]([NH:1][CH2:2][C:3]([OH:5])=[O:4])=[O:8]Participants
3
Procedure
2 mmoles of Boc-Gly-Rx were used as starting material, and 0.90 g of pGlu were added according to the usual principles for solid peptide synthesis.
Workup
- additionwere added
Sources & evidence
- ORD record
- ord-f9fdfceba0f24412be332e3a9f318530
- Source dataset
- uspto-grants-1989_09
- Patent number
- US04868156
Reaction notes
Loading…