Sodium → HCID 178444960, compound

HRID 1609290

Reaction equation

HRID 1609290 reaction equation
[NH:1]1[C:5]([CH:6]([O:8][C:9]2[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=2)[O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20](=[O:34])[C:21]2[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:23][CH:22]=2)[CH3:7])=[N:4][N:3]=[N:2]1.[Na:38]>CCOCC.C(O)C>[Na:38].[NH:4]1[C:5]([CH:6]([O:8][C:9]2[CH:10]=[C:11]([CH:35]=[CH:36][CH:37]=2)[O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[NH:19][C:20](=[O:34])[C:21]2[CH:22]=[CH:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])=[CH:25][CH:26]=2)[CH3:7])=[N:1][N:2]=[N:3]1

Participants

5

Reactant 2

HCID 5360545SodiumHCID 178444959HCID 178444959, compound

Product 1

HCID 178444960HCID 178444960, compoundYield 92.5%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

In 30 ml of ether was dissolved 2.0 g of N-[2-[3-[1-(1H-tetrazol-5-yl)ethoxy]phenoxy]phenyl]-4-hexyloxybenzamide followed by addition of a solution of 90 mg of sodium in ethanol, and the mixture was concentrated in vacuo to dryness. After addition of isopropyl ether, the resulting foamy solid was pulverized, filtered and dried to give 1.9 g of the sodium salt as a white amorphous powder.

Workup

  1. concentrationthe mixture was concentrated in vacuo to dryness
  2. additionAfter addition of isopropyl ether
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-d1a9acbae6d7492d8361972f84ec0462
Source dataset
uspto-grants-1995_03
Patent number
US05399703

Linked notes

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