Tetrahydrofuran → Tert-butyl 4-[[5-benzylsulfanyl-7-[(1-hydroxy-4-methylpentan-2-yl)amino]-[1,3]thiazolo[4,5-d]pyrimidin-2-yl]amino]piperidine-1-carboxylate

HRID 161018

Reaction equation

HRID 161018 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[s:16][c:17]3[c:18]([n:19][c:20]([S:24][CH2:25][c:26]4[cH:27][cH:28][cH:29][cH:30][cH:31]4)[n:21][c:22]3[Cl:23])[n:32]2)[CH2:12][CH2:13]1.[NH2:33][CH:34]([CH2:35][CH:36]([CH3:37])[CH3:38])[CH2:39][OH:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][c:15]2[s:16][c:17]3[c:18]([n:19][c:20]([S:24][CH2:25][c:26]4[cH:27][cH:28][cH:29][cH:30][cH:31]4)[n:21][c:22]3[NH:33][CH:34]([CH2:35][CH:36]([CH3:37])[CH3:38])[CH2:39][OH:40])[n:32]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 790302-Amino-4-methylpentan-1-olHCID 867601104(5-Phenylmethylthio-7-chloro-thiazolo[4,5-d]pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 87798491Tert-butyl 4-[[5-benzylsulfanyl-7-[(1-hydroxy-4-methylpentan-2-yl)amino]-[1,3]thiazolo[4,5-d]pyrimidin-2-yl]amino]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-01ffd98e92574afcab5a8aca93f44422
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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