Ammonium Hydroxide → beta-Phenyl-L-phenylalanine

HRID 1614697

Reaction equation

HRID 1614697 reaction equation
Cl.[C:2]1([CH:8]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+]>O>[C:2]1([CH:8]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C@@H:9]([C:11]([OH:13])=[O:12])[NH2:10])[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 70136519(S)-2-Amino-3,3-diphenylpropanoic acid hydrochloride

Product 1

HCID 162977beta-Phenyl-L-phenylalanineYield 46%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

D (-)-3,3-Diphenylalanine hydrochloride (0.5 g) is dissolved in 15 mL of water and the pH of the solution is adjusted with dilute ammonium hydroxide solution to pH 7. The precipitate is collected by filtration, washed with water, boiled with water for a short time, cooled to room temperature, and collected to afford 0.2 g of the title compound; mp 218°-220° C. (dec.).

Workup

  1. filtrationThe precipitate is collected by filtration
  2. washwashed with water
  3. customcollected

Sources & evidence

ORD record
ord-138ffbe38f4746daa81b966f03e18082
Source dataset
uspto-grants-1993_03
Patent number
US05198548

Linked notes

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