Glycerol → 1,7-Naphthyridin-8-amine

Temperature

135 °C

A mixture of pyridine-2,3-diamine (5.0 g, 45.9 mmol), glycerol (21.1 g, 229 mmol), sodium 3-nitrobenzenesulphonate (20.6 g, 91.7 mmol), sulfuric acid (20 mL) and water (30 mL) was heated to 135° C. and stirred for 16 h. The mixture was cooled to room temperature and then poured into ice/water (150 g). The mixture was adjusted to pH ˜9 with saturated NaOH aqueous solution. Then the mixture was extracted with EtOAc (3×100 mL). The combined organic layers were dried over sodium sulfate and concentrated under reduce pressure to give the crude product, which was purified by silica gel column (eluting with PE/EtOAc v/v 2:1) to give 1,7-naphthyridin-8-amine as a yellow solid (2.6 g, yield 39%). ESI MS: m/z 146.1 [M+H]+.

1. temperatureThe mixture was cooled to room temperature
2. extractionThen the mixture was extracted with EtOAc (3×100 mL)
3. dry with materialThe combined organic layers were dried over sodium sulfate
4. concentrationconcentrated
5. customto give the crude product, which
6. customwas purified by silica gel column (
7. washeluting with PE/EtOAc v/v 2:1)

ORD record

ord-e4d98668244840ff91d551adbbe190b8

Source dataset

uspto-grants-2014_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08765760B2