Trifluoroacetic acid → HCID 67284671, compound
Reaction equation
[N:1]1([C:7]2[CH:12]=[C:11]3[N:13](C(OC(C)(C)C)=O)[CH2:14][C:15]4([CH2:20][CH2:19][S:18](=[O:22])(=[O:21])[CH2:17][CH2:16]4)[C:10]3=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[N:1]1([C:7]2[CH:12]=[C:11]3[NH:13][CH2:14][C:15]4([CH2:20][CH2:19][S:18](=[O:21])(=[O:22])[CH2:17][CH2:16]4)[C:10]3=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of tert-butyl 6-(4-morpholinyl)-2′,3′,5′,6′-tetrahydrospiro-[indole-3,4′-thiopyran]-1(2H)-carboxylate 1′,1′-dioxide (60 mg, 0.142 mmol) in DCM (1 mL) was added TFA (438 μL, 5.68 mmol) and the reaction was stirred at rt for 1 h. After this time the reaction was evaporated in vacuo and dried on the vacuum pump overnight. The resulting residue was then partitioned between DCM (40 mL) and NaHCO3 (10 mL, sat. aqueous solution). The separated organic layer was dried over MgSO4, filtered and evaporated in vacuo to give 6-morpholin-4-yl-1,2,2′,3′,5′,6′-hexahydrospiro[indole-3,4′-thiopyran]1′,1′-dioxide. Mass Spectrum (ESI) m/e=323.2 (M+1).