Potassium Carbonate → HCID 86762491, compound

Reaction equation

[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8]([OH:12])=[CH:7]2.C(=O)([O-])[O-].[K+].[K+].C[C:20]([C:22]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:23]=1F)=[O:21]>C(#N)C>[F:28][C:27]1[CH:26]=[CH:25][CH:24]=[C:23]([O:12][C:8]2[CH:9]=[N:10][C:11]3[C:6]([CH:7]=2)=[CH:5][CH:4]=[CH:3][C:2]=3[F:1])[C:22]=1[CH:20]=[O:21]

Participants

Procedure

After 30 ml of acetonitrile was added to 3.0 g of 8-fluoro-3-hydroxyquinoline, 3.1 g of potassium carbonate and 3.5 g of 2,6-difluoroacetophenone were added. After the reaction solution was heated under reflux for 3 hours, the reaction solution was filtered with CELITE. After the filtrate was extracted with ethyl acetate, the organic layer was concentrated and purified by silica gel column chromatography to obtain 3.0 g of 2-fluoro-6-(8-fluoroquinolin-3-yloxy)-benzaldehyde (Compound Number 341).