HCID 178524562, compound → 2-Oxopiperidine-4-carboxylic acid
Reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([C:8]([OH:10])=[O:9])[CH:5]=[CH:4][N:3]=1>CO.[OH-].[OH-].[Pd+2]>[O:1]=[C:2]1[CH2:7][CH:6]([C:8]([OH:10])=[O:9])[CH2:5][CH2:4][NH:3]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
A solution of 2-hydroxypyridine-4-carboxylic acid (40.0 g) and 10% palladium hydroxide/carbon (8.0 g) in methanol (500 mL) was stirred at 30° C. for 24 hr under a hydrogen atmosphere (50 psi). The reaction mixture was filtered, the catalyst was removed, and the filtrate was concentrated under reduced pressure to give the title compound (38.0 g).
Workup
- filtrationThe reaction mixture was filtered
- customthe catalyst was removed
- concentrationthe filtrate was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-5125ef58daf14fa286ae2313d286450d
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772277B2
Reaction notes
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