Triethylamine → HCID 178484615, compound
Reaction equation
Cl.[CH3:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5][NH2:6].C(N(CC)CC)C.S=[C:17]1[CH2:21][S:20][C:19](=[O:22])[NH:18]1>C(O)C>[CH3:2][N:3]([CH3:8])[C:4](=[O:7])[CH2:5][NH:6][C:17]1[CH2:21][S:20][C:19](=[O:22])[N:18]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of N,N-dimethylglycinamide hydrochloride (5 g) and triethylamine (5.03 mL) in ethanol (20 mL) was added 4-thioxo-1,3-thiazolidin-2-one (4.81 g), and the mixture was stirred at room temperature for 4 hr. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (NH, ethyl acetate/THF) to give the title compound (4.68 g).
Workup
- concentrationThe reaction mixture was concentrated
- customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/THF)
Sources & evidence
- ORD record
- ord-7c043bb9975b4ca5a3935a496f5eff19
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772277B2
Reaction notes
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