Iodine → 2-(2,5-Dibromophenyl)benzo[d]thiazole
Reaction equation
[Br:1][C:2]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][C:3]=1[CH:4]=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[SH:18].II>CN(C=O)C>[Br:1][C:2]1[CH:9]=[CH:8][C:7]([Br:10])=[CH:6][C:3]=1[C:4]1[S:18][C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[N:11]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5 g (18.5 mmol) of 2,5-dibromobenzaldehyde, 3 mL (27.7 mmol) of 2-aminothiophenol, and 2.35 g (9.25 mmol) of iodine were dissolved in 100 mL of DMF. The solution was reacted at 100° C. for 1 hour. The obtained reactant was purified through a column, obtaining 4.64 g (Y=68%) of a white solid.
Workup
- customThe solution was reacted at 100° C. for 1 hour
- customThe obtained reactant was purified through a column
- customobtaining 4.64 g (Y=68%) of a white solid
Sources & evidence
- ORD record
- ord-37883f45c01f4c958b3de168b018472d
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08772632B2
Reaction notes
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