2,6-Dibromopyridine → 2-Bromo-6-(4-fluoro-benzyl)-pyridine
Reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[N:3]=1.[Br-].[F:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][Zn+])=[CH:13][CH:12]=1>>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH2:15][C:14]2[CH:17]=[CH:18][C:11]([F:10])=[CH:12][CH:13]=2)[N:3]=1Participants
3
Procedure
Prepared according to the procedure described in Example 53, Step 2, using 2,6-dibromo-pyridine and 4-fluoro-benzylzinc bromide.
Workup
- customPrepared
Sources & evidence
- ORD record
- ord-193e86d8891341429bb922f2517fada4
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08778983B2
Reaction notes
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