18-Crown-6 → 1-{4-[3-(Difluoromethyl)-2-oxoimidazolidin-1-yl]-2-fluorophenyl}-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one

Reaction equation

[F:1][C:2]1[CH:7]=[C:6]([N:8]2[CH2:12][CH2:11][NH:10][C:9]2=[O:13])[CH:5]=[CH:4][C:3]=1[N:14]1[CH:19]=[C:18]([O:20][CH3:21])[C:17](=[O:22])[C:16]([C:23]2[N:27]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[N:26]=[CH:25][CH:24]=2)=[N:15]1.Cl[C:35]([F:40])([F:39])C([O-])=O.[Na+].C1OCCOCCOCCOCCOCCOC1>C(#N)C>[F:39][CH:35]([F:40])[N:10]1[CH2:11][CH2:12][N:8]([C:6]2[CH:5]=[CH:4][C:3]([N:14]3[CH:19]=[C:18]([O:20][CH3:21])[C:17](=[O:22])[C:16]([C:23]4[N:27]([C:28]5[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=5)[N:26]=[CH:25][CH:24]=4)=[N:15]3)=[C:2]([F:1])[CH:7]=2)[C:9]1=[O:13]