Hydrazine hydrate (1:1) → 3,5-Diamino-4-(4-ethylphenylmethyl)pyrazole
Reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([C:13]#[N:14])[C:11]#[N:12])=[CH:5][CH:4]=1)[CH3:2].O.[NH2:16][NH2:17]>C(O)C>[NH2:12][C:11]1[C:10]([CH2:9][C:6]2[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=2)=[C:13]([NH2:14])[NH:17][N:16]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of the above 2-(4-ethylphenylmethyl)malononitrile (1.30 g) and hydrazine hydrate (0.86 ml) in ethanol (35 ml) was heated under reflux for 4 hours. Hydrazine hydrate (0.43 ml) was further added thereto and the mixture was further heated under reflux for 4 hours. The reaction mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. The residue was crystallized from ethyl acetate-diethyl ether to give 3,5-diamino-4-(4-ethylphenylmethyl)pyrazole (2.63 g) as pale pink powder. APCI-Mass m/Z 217 (M+H).