Hydrochloric Acid → HCID 6415827, compound
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=[O:12])=[CH:5][CH:4]=1.[N:13](OCCC(C)C)=[O:14].Cl>CO>[OH:14]/[N:13]=[C:8]1/[C:9](=[O:12])[C:10]2[C:6]([CH2:7]/1)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:11]=2Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
6-methoxy-2,3-dihydro-1H-inden-1-one (17.2 g, 106 mmol) was dissolved in methanol (700 mL). The mixture was heated to 40° C., then isoamyl nitrite (30 mL, 220 mmol) and concentrated hydrochloric acid (17 mL) were added. The reaction mixture was stirred at 40° C. for 2 hours. After cooled to room temperature, the precipitate was collected by filtration and dried under high vacuum to obtain product (10.0 g, yield 50%).
Workup
- temperatureAfter cooled to room temperature
- filtrationthe precipitate was collected by filtration
- customdried under high vacuum
Sources & evidence
- ORD record
- ord-a139e862b543480f9763e088ee757281
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08785643B2
Reaction notes
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