Trifluoroacetic acid → (S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxypropylamine
Reaction equation
C([NH:8][C@H:9]([C:14]1[NH:18][C:17]2[CH:19]=[CH:20][C:21]([Cl:23])=[CH:22][C:16]=2[N:15]=1)[CH2:10][CH2:11][O:12][CH3:13])(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>ClCCl>[Cl:23][C:21]1[CH:20]=[CH:19][C:17]2[NH:18][C:14]([C@@H:9]([NH2:8])[CH2:10][CH2:11][O:12][CH3:13])=[N:15][C:16]=2[CH:22]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared analogously to Example 1g from (1S)-N-Boc-1-(5-chloro-1H-benzimidazol-2-yl)-3-methoxy-propylamine and TFA in dichloromethane.
Sources & evidence
- ORD record
- ord-d0c0e9484ed642e6a422af8c32d5da04
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08791103B2
Reaction notes
Loading…