Sodium Hydroxide → Pentiapine

HRID 1632687Notes

Reaction equation

HRID 1632687 reaction equation
[C:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1)(OCC)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-].[OH-].[Na+]>O1CCCC1>[CH3:1][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 131782745-(4-Carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepineHCID 21226445Aluminium lithium hydride

Product 1

HCID 54742Pentiapine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the solution of 0.2 g of 5-(4-carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 2 ml of dry tetrahydrofuran, 100 mg of lithium aluminum hydride are added at once and the mixture is refluxed under nitrogen for 48 hrs. The mixture is cooled to room temperature, stirred with 0.2 ml of 30% sodium hydroxide, and filtered. The filtrates were evaporated to dryness and the product is purified to give 5-(4-methylpiperazino]-imidazo[2,1-b][1,3,5]benzothiadiazepine, melting at 145°-7°, and identical to compound obtained in example 1.

Workup

  1. temperatureis refluxed under nitrogen for 48 hrs
  2. filtrationfiltered
  3. customThe filtrates were evaporated to dryness
  4. customthe product is purified

Sources & evidence

ORD record
ord-e5b6615b099542668024cb5f780573ae
Source dataset
uspto-grants-1984_10
Patent number
US04477379

Reaction notes

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