Triethylamine → 1-(3,4,5-Trimethoxycinnamoyl)-4-[1-(isopropylaminocarbonyl)ethyl]piperazin

HRID 1632968Notes

Reaction equation

HRID 1632968 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]=[CH:7][C:8](Cl)=[O:9].C(N(CC)CC)C.[CH:25]([NH:28][C:29]([CH:31]([N:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1)[CH3:32])=[O:30])([CH3:27])[CH3:26]>C(Cl)(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15])[CH:6]=[CH:7][C:8]([N:36]1[CH2:35][CH2:34][N:33]([CH:31]([C:29]([NH:28][CH:25]([CH3:27])[CH3:26])=[O:30])[CH3:32])[CH2:38][CH2:37]1)=[O:9]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1120942-Propenoyl chloride, 3-(3,4,5-trimethoxyphenyl)-, (2E)-HCID 13454833N-isopropyl-2-(piperazin-1-yl)propanamide

Product 1

HCID 543786781-(3,4,5-Trimethoxycinnamoyl)-4-[1-(isopropylaminocarbonyl)ethyl]piperazin

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

15.15 g of 3,4,5-trimethoxycinnamoyl chloride and 8.92 ml of triethylamine are added with ice cooling and stirring to a solution of 9.80 g of 1-[1-(isopropylaminocarbonyl)ethyl]piperazine in 200 ml of chloroform, and the resulting solution is stirred at room temperature for 1 hour.

Sources & evidence

ORD record
ord-aa59b44bbc794d568f0249f8dc72d4af
Source dataset
uspto-grants-1984_10
Patent number
US04478838

Reaction notes

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