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p-(Trifluoromethoxy)phenyl isocyanate → HCID 23550123, compound

HRID 1633962
Notes
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Reaction equation

HRID 1633962 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:19]=[CH:18][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:9])=[CH:6][CH:5]=1.[F:20][C:21]([F:33])([F:32])[O:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]=[C:30]=[O:31])=[CH:25][CH:24]=1>C(#N)C.C(N(C(C)C)CC)(C)C>[CH2:16]([O:15][C:13](=[O:14])[CH2:12][CH2:11][NH:10][C:8](=[O:9])[C:7]1[CH:6]=[CH:5][C:4]([CH2:3][NH:2][C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([O:22][C:21]([F:20])([F:32])[F:33])=[CH:24][CH:25]=2)=[O:31])=[CH:19][CH:18]=1)[CH3:17]
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 2

HCID 92298p-(Trifluoromethoxy)phenyl isocyanateHCID 22502125HCID 22502125, compound

Product 1

HCID 23550123HCID 23550123, compound

Reagents, catalysts & solvents 2

HCID 6342AcetonitrileSolventHCID 81531DiisopropylethylamineSolvent

Conditions

Temperature
25 °C

Procedure

Ethyl 3-(4-Aminomethylbenzoylamino)propanoate hydrochloride (0.25 g, 0.87 mmol) in acetonitrile (5 mL) and diisopropylethylamine (0.15 mL) was allowed to react with 4-trifluoromethoxyphenylisocyanate (0.37 g, 1.74 mmol) at 50° C. overnight. Upon cooling to 25° C. the product precipitated and was collected by filtration.

Workup

  1. customprecipitated
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-9518547eb2344ad68774dd5f9ba97e69
Source dataset
uspto-grants-2003_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06503949B1

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes