HCID 22136184, compound → HCID 22136173, compound
Reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([CH2:15][NH:16][C:17](=O)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[N:7][CH:6]=1)=[O:4]>O=P(Cl)(Cl)Cl>[C:18]1([C:17]2[N:7]3[CH:6]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[C:14]4[C:9]([C:8]3=[CH:15][N:16]=2)=[CH:10][CH:11]=[CH:12][CH:13]=4)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 105 °C
Procedure
A mixture of the product from part 7 (1.97 g) in 10 ml of POCl3 is stirred at 105° C. for two hours, then cooled and concentrated under vacuum. The residue is treated with EtOAc and washed with saturated aqueous NaHCO3 solution and water. The organic solution is dried over Na2SO4, filtered and then concentrated to afford a solid. Recrystallization from 2-propanol yields the title compound as a yellow solid (0.7 g).