Hydrochloric Acid → HCID 2756354, compound

Reaction equation

C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([NH2:17])[CH:12]=2)=[CH:7][CH:6]=1)=[O:4].[ClH:18]>>[ClH:18].[NH2:17][C:13]1[CH:12]=[C:11]([C:8]2[CH:9]=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=2)[CH:16]=[CH:15][CH:14]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 1393986Methyl 4-(3-aminophenyl)benzoate

Product 1

HCID 2756354HCID 2756354, compoundYield 96%

Conditions

Temperature: 60 °C

Procedure

A mixture of 1-4 (500 mg, 2.20 mmol) and 6N HCl (50 mL) was heated at 60° C. for 20 h. Evaporative removal of the solvent provided 1-5 (530 mg, 96%) as a white solid.

Workup

customEvaporative removal of the solvent

Sources & evidence

ORD record: ord-314272b9a17f412383788308821269ca
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06040311

Reaction notes

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