Diethylamine → HCID 12539734, compound

Reaction equation

[N:1]1([CH2:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH2:6][CH2:5]O[CH2:3][CH2:2]1.Cl.N1C=CC(CCl)=CC=1.C(NCC)C>>[CH2:2]([N:1]([CH2:7][C:8]1[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=1)[CH2:6][CH3:5])[CH3:3]

Participants

Reactant 3

HCID 8021Diethylamine

HCID 745704-(Chloromethyl)pyridinium chloride

HCID 12291568HCID 12291568, compound

Product 1

HCID 12539734HCID 12539734, compoundYield 88%

Procedure

In a manner similar to the procedure described for the synthesis of 4-(4-morpholinyl)methylpyridine, 4-picolylchloride hydrochloride (6.00 g, 0.0366 mol) and diethylamine (10.68 g, 0.146 mol, 4.0 equiv.) provided 5.28 g (88%) of 4-(N,N-diethylaminomethyl)pyridine.

Sources & evidence

ORD record: ord-9db6e8bc8a1b477b9ac8d7786a1d66bf
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06043248

Reaction notes

Loading…