2-Amino-4-(p-nitrophenyl)thiazole → 2-Amino-4-(4-aminophenyl)thiazole
Reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)[N:6]=1>CN(C=O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=2)[N:6]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
Prepared by 2 hours' hydrogenation of 2-amino-4-(4-nitro-phenyl)-thiazole (melting point: 287-291° C.; prepared from ω-bromo-4-nitro-acetophenone and thiourea) in DMF on palladium/charcoal (10%) at 20° C.
Sources & evidence
- ORD record
- ord-be4ae694ac25499fa8fc165414f891c9
- Source dataset
- uspto-grants-2000_03
- Patent number
- US06043254
Reaction notes
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