Sulfur → 6,7-Dimethoxy-2-naphthoic acid

HRID 1638783Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[CH2:9][CH2:8][C:7]([C:15]([OH:17])=[O:16])=[CH:6]2.[S]>>[CH3:14][O:13][C:12]1[CH:11]=[C:10]2[C:5](=[CH:4][C:3]=1[O:2][CH3:1])[CH:6]=[C:7]([C:15]([OH:17])=[O:16])[CH:8]=[CH:9]2

Participants

Reactant 2

HCID 5362487Sulfur

HCID 14676173HCID 14676173, compound

Product 1

HCID 2830286,7-Dimethoxy-2-naphthoic acidYield 94.9%

Conditions

Temperature: 215 °C

Procedure

A mixture of 6,7-dimethoxy-1,2-dihydro-3-naphthoic acid (1.7 g) and powdery sulfur (0.47 g) is heated at 215° C. for 30 minutes to afford 6,7-dimethoxy-2-naphthoic acid (1.6 g), which is recrystallized from ethanol to give colorless prisms, m.p. 245°-247° C.

Sources & evidence

ORD record: ord-d454b56016524796afa8fbba1f159fcd
Source dataset: uspto-grants-1989_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04880809

Reaction notes

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