Sodium ion → N-(1-azabicyclo[2.2.2]octan-3-yl)-6-(4-morpholin-4-ylphenyl)-1-benzofuran-2-carboxamide

HRID 164117

Reaction equation

HRID 164117 reaction equation
[N:16]12[CH2:17][CH:18]([NH:24][C:25](=[O:26])[c:27]3[o:28][c:29]4[c:30]([cH:31]3)[cH:32][cH:33][c:34]([Br:36])[cH:35]4)[CH:19]([CH2:20][CH2:21]1)[CH2:22][CH2:23]2.[Na+:38].[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[cH:8][cH:9][c:10]([B:13]([OH:14])[OH:15])[cH:11][cH:12]2)[CH2:5][CH2:6]1.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH-:37]>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[cH:8][cH:9][c:10](-[c:34]3[cH:33][cH:32][c:30]4[c:29]([o:28][c:27]([C:25]([NH:24][CH:18]5[CH2:17][N:16]6[CH2:21][CH2:20][CH:19]5[CH2:22][CH2:23]6)=[O:26])[cH:31]4)[cH:35]3)[cH:11][cH:12]2)[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 923Sodium ionHCID 961HydroxideHCID 6228DimethylformamideHCID 2795359(4-(Morpholin-4-yl)phenyl)boronic acidHCID 17982681N-(1-azabicyclo[2.2.2]octan-3-yl)-6-bromo-1-benzofuran-2-carboxamide

Product 1

HCID 17982650N-(1-azabicyclo[2.2.2]octan-3-yl)-6-(4-morpholin-4-ylphenyl)-1-benzofuran-2-carboxamide

Sources & evidence

ORD record
ord-0a8aadb67d9242cbb8bbcc0790904660
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Linked notes

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