HCID 57619809, compound → HCID 55288821, compound
Reaction equation
[C:1]([CH2:3][C@H:4]1[CH2:9][CH2:8][CH2:7][CH2:6][C@@H:5]1[NH:10]C(=O)OC(C)(C)C)#[N:2]>CO.Cl.O1CCOCC1>[NH2:10][C@H:5]1[CH2:6][CH2:7][CH2:8][CH2:9][C@@H:4]1[CH2:3][C:1]#[N:2]Participants
5
Reactant 1
Product 1
Reagents, catalysts & solvents 3
Procedure
A solution tert-butyl N-[(1S,2R)-2-(cyanomethyl)cyclohexyl]carbamate (2 g) in MeOH (40 mL) and 4 M HCl in dioxane (20 mL) was stirred at room temperature for 2 hours and concentrated in vacuo to provide the title compound as a yellow oil, which was used for the subsequent step without further purification.
Workup
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-5d866fdb39624dafadd68d6fe0a7198a
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08119661B2
Reaction notes
Loading…