Hydroxylamine HCl → 3,4-difluoro-N'-hydroxybenzenecarboximidamide
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[C:5]#[N:6].[Cl-].[OH:12][NH3+:13].C(=O)(O)[O-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[C:4]([C:5](=[N:13][OH:12])[NH2:6])[CH:7]=[CH:8][C:9]=1[F:10]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
1.0 g (7.2 mmol) of 3,4-difluorobenzonitrile was initially charged in 30 ml of ethanol, and a solution of 0.5 g (7.2 mmol) of hydroxylammonium chloride and 0.6 g (7.2 mmol) of sodium bicarbonate in 11 ml of water was added at RT. The reaction mixture was stirred at RT for 16 h, concentrated under reduced pressure and reacted without further purification.
Workup
- concentrationconcentrated under reduced pressure
- customreacted without further purification
Sources & evidence
- ORD record
- ord-f318a85fe057494a808fb1f517fdf0ad
- Source dataset
- uspto-grants-2012_02
- Patent number
- US08119663B2
Reaction notes
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