Hydrochloric Acid → HCID 178434283, compound

HRID 16432

Reaction equation

HRID 16432 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH2:19])[CH:5]=[CH:6][C:7]=1[O:8][C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[C:11]([CH3:18])=[N:12][NH:13]2.Cl[C:21]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[N:24]=[C:23]([NH2:33])[N:22]=1.Cl>O>[NH2:33][C:23]1[N:22]=[C:21]([NH:19][C:4]2[CH:5]=[CH:6][C:7]([O:8][C:9]3[CH:17]=[CH:16][CH:15]=[C:14]4[C:10]=3[C:11]([CH3:18])=[N:12][NH:13]4)=[C:2]([F:1])[CH:3]=2)[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[N:24]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 223242864-Chloro-6-(pyridin-4-yl)pyrimidin-2-amineHCID 178434284HCID 178434284, compound

Product 1

HCID 178434283HCID 178434283, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

60 mg (0.23 mmol) of 3-fluoro-4-[(3-methyl-1H-indazol-4-yl)oxy]phenylamine (from example III) and 48 mg (0.23 mmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) are suspended in 4 ml of water, and 0.02 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a brown precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum. This gives 65 mg (65% of theory) of the product as a brown solid.

Workup

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux overnight
  3. customresulting in the formation of a brown precipitate
  4. filtrationThis is filtered off
  5. washwashed repeatedly with water
  6. customdried under high vacuum

Sources & evidence

ORD record
ord-fc7964a9bad242aa803848e6a997f850
Source dataset
uspto-grants-2010_06
Patent number
US07737153B2

Linked notes

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