Hydrochloric Acid → N-(3-pyrrolidyl)phthalimide hydrochloride

HRID 1645847

Reaction equation

HRID 1645847 reaction equation
C([N:8]1[CH2:12][CH2:11][CH:10]([N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[CH2:9]1)C1C=CC=CC=1.[ClH:24]>C(O)C.[C].[Pd]>[ClH:24].[NH:8]1[CH2:12][CH2:11][CH:10]([N:13]2[C:17](=[O:18])[C:16]3=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]3[C:14]2=[O:23])[CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 6711061N-(1-benzylpyrrolidin-3-yl)phthalimide

Product 1

HCID 22926344N-(3-pyrrolidyl)phthalimide hydrochloride

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

12.70 g of N-(1-benzylpyrrolidin-3-yl)phthalimide was dissolved in 100 ml of ethanol and then subjected to hydrogenating decomposition with addition of 1.0 g of 10% palladium-carbon and 5.2 ml of concentrated hydrochloric acid at 60° C. under 1 atm. After 12 hours, the catalyst was filtered out and the solvent was distilled off to obtain 11.03 g of N-(3-pyrrolidyl)phthalimide hydrochloride.

Workup

  1. filtrationthe catalyst was filtered out
  2. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-70e814cce8244dbe9f35ae67fdb45664
Source dataset
uspto-grants-1993_01
Patent number
US05177089

Linked notes

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