Glycolic Acid → Formate

HRID 1646712

Reaction equation

HRID 1646712 reaction equation
[C:1]([OH:5])(=[O:4])[CH2:2][OH:3].CC1ONC(=[O:10])C=1CC(N)[C:15]([OH:17])=[O:16]>>[C:1]([O-:5])(=[O:4])[CH:2]=[O:3].[CH:15]([O-:17])=[O:16].[C:2]([O-:10])(=[O:3])[C:1]([O-:5])=[O:4]

Participants

5

Reactant 2

HCID 757Glycolic Acid2×HCID 1221alpha-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID

Product 3

HCID 283FormateHCID 71081OxalateHCID 3614358Npc324351

Procedure

The enzymatic oxidation of glycolic acid in Example 5 was repeated at pH 8.5, and using initial concentrations of glycolic acid and AMPA of 0.50M and 0.40M, respectively. After 16.5 h, the HPLC yields of glyoxylate, formate, and oxalate were 85.4%, 3.5%, and 6.3%, respectively, and 1.4% glycolate remained. The final pH of the reaction mixture was 7.0.

Sources & evidence

ORD record
ord-cac0e7d3df57469ca85c8d9671964b52
Source dataset
uspto-grants-1993_01
Patent number
US05180846

Linked notes

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