Phosphorus oxychloride → 1-Ethyl-4-chloro-5-cyano-2,3,6,7-tetrahydro-1H-azepine

Reaction equation

[CH2:1]([N:3]1[CH2:9][CH2:8][C:7](=[C:10]=[N:11]O)[CH:6]([Cl:13])[CH2:5][CH2:4]1)[CH3:2].P(Cl)(Cl)(Cl)=O>>[CH2:1]([N:3]1[CH2:9][CH2:8][C:7]([C:10]#[N:11])=[C:6]([Cl:13])[CH2:5][CH2:4]1)[CH3:2]

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 204813261-ethyl-4-chloro-2,3,6,7-tetrahydro-5-oximinomethylene-1H-azepine

Product 1

HCID 204813561-Ethyl-4-chloro-5-cyano-2,3,6,7-tetrahydro-1H-azepine

Procedure

This compound was prepared from 1-ethyl-4-chloro-2,3,6,7-tetrahydro-5-oximinomethylene-1H-azepine and phosphorus oxychloride analogous to Example E.

Sources & evidence

ORD record: ord-2b6f47dd944444b6940896fc00577113
Source dataset: uspto-grants-1983_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04414225

Reaction notes

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